Events The 15th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Bioorganic, Medicinal and Natural Products of the event The 15th International Electronic Conference on Synthetic Organic Chemistry

Published date

27 Oct, 2011

Citation

Jaroslaw Polanski, Jacek Finster, Wioleta Kowalczyk, Katarina Kralova, Matus Pesko, Josef Jampilek, Robert Musiol, Preparation and Herbicidal Properties of Ring-Substituted 4-Chloro-2-styrylquinazolines, in Proceedings of The 15th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2011, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-15-00586

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Preparation and Herbicidal Properties of Ring-Substituted 4-Chloro-2-styrylquinazolines

Jaroslaw Polanski ¹

Jacek Finster ¹

Wioleta Kowalczyk ¹

Katarina Kralova ²

Matus Pesko ³

Josef Jampilek ⁴

Robert Musiol ¹

1. Institute of Chemistry, University of Silesia, Szkolna 9; 40-007, Katowice Poland

2. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia

3. Department of Ecosozology and Physiotactics, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia

4. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic

Abstract

In this study, a series of new seven ring-substituted 4-chloro-2-styrylquinazoline derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).

Keywords

4-chloro-2-styrylquinazoline derivatives

Lipophilicity

PET inhibition

Spinach chloroplasts

Structure-activity relationships

Synthesis of 2,1-benzisoxazol-3(1H)-one by intramolecular photochemical cyclization of 2-azidobenzoic acid.

Preparation and Herbicidal Properties of Substituted Quinoline-2-carboxanilides