EventsMOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Event submissions
Published
with-doi10.3390/mol2net-04-05865
This submission belongs to the session 04. AIMEDIC-06: AI, Med. Info., & Biomed. Eng. Congress, Coruña, Spain-Miami, USA, 2018. of the event MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Published date
19 Nov, 2018
Citation
Fabienne Dioury, Sophie Laurent, Marie Devreux, Céline Henoumont, Clotilde Ferroud, Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization, in Proceedings of MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed., 15 January 2018–20 January 2019, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-04-05865
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Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization

Marie Devreux 1
Fabienne Dioury 2
Céline Henoumont 1
Clotilde Ferroud 3
image
Sophie Laurent 1,4
1. Université de Mons, Chimie Générale, Organique et Biomédicale, Laboratoire de RMN et d’Imagerie Moléculaire, 19 Avenue Maistriau, 7000 Mons (Belgique)
2. HESAM Université, Conservatoire national des arts et métiers, Laboratoire CMGPCE, 2 rue Conté, 75003 Paris (France)
3. Hesam Université, Conservatoire national des arts et métiers, Laboratoire CMGPCE, 2 rue Conté, F-75003 Paris, France
4. Centre de Microscopie et d’Imagerie Moléculaire, 8 rue Adrienne Bolland, 6041 Charleroi (Belgique)
Abstract

Multimodality imaging based on complementary modalities is a way to improve the accuracy of medical diagnosis. For such purpose, multimodal probes combining the appropriate contrastophores into a single delivery are required. The project presented here deals with the combination of two modalities: MRI, and photoacoustic imaging (PAI). The dual probe envisaged is based on a gadolinium chelate as contrast-agent for MRI, and the ZW800-1 fluorophore for PAI, both of them being grafted on a L-lysine linker. The results presented describe the synthesis pathway, and the relaxometric characterization of the dual compound.

Keywords
medical imaging
molecular imaging
multi-modalities
MRI
photoacoustic
bifunctional chelating agent
gadolinium chelate
PCTA
ZW800-1
Manuscript
Mol2Net-04_2018_BIOCHEMPHYS-01_AO_revised.pdf
Poster
Mol2Net-04_2018_BIOCHEMPHYS-01_AO_revised.pdf
Mol2Net-04_2018_BIOCHEMPHYS-01_AO_revised.pdf
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