EventsMOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Event submissions
Published
with-doi10.3390/mol2net-04-06135 (registering DOI)
This submission belongs to the session 05. MODEC-03: Workshop on Natural Products and Agro-Industrial Procesess in Amazon, UEA, Puyo, Ecuador, 2018 of the event MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Published date
14 Jan, 2019
Citation
Manel Ben Ali, Mouna jlidi, Adel HAJ BRAHIM, Lobna DAOUD, Houda HMANI, Samir BEJAR, Mamdouh BEN ALI, ANTIVIRAL ACTIVITY OF THE ESSENTIAL OIL OF CONYZA CANADENSIS, in Proceedings of MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed., 15 January 2018–20 January 2019, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-04-06135
Share
Email
Facebook
Twitter
LinkedIn

ANTIVIRAL ACTIVITY OF THE ESSENTIAL OIL OF CONYZA CANADENSIS

image
Manel Ben Ali 1,2
Lobna DAOUD 1
Adel HAJ BRAHIM 1
Houda HMANI 1
Mouna jlidi 1
Samir BEJAR 1
Mamdouh BEN ALI 1,2
1. Laboratory of Microbial Biotechnology and Engineering Enzymes (LBMIE), Center of Biotechnology of Sfax (CBS), University of Sfax, Road of Sidi Mansour km 6, PO Box 1177 Sfax 3018, Tunisia.
2. Astrum Biotech, Business incubator, Center of Biotechnology of Sfax (CBS), University of Sfax, Road of Sidi Mansour km 6, PO Box 1177 Sfax 3018, Tunisia.
Abstract

In this study, we were interested in the characterization of Conyza canadensis essential oil composition and evaluation of the antiviral activity from Conyza’s plant extracts. Terpenoids, phenols, sesquiterpenoids and triterpenoids were the major compounds identified from plant essential oil analyzed by gas-chromatography coupled to mass spectrometry.
The test of activities of the extracts from different parts (leave, flower and stalk) of Conyza canadensis revealed that this plant has a remarkable antiviral activity. This activity was evaluated for inhibition of Dengue virus (DV), West Nile virus (WNV), Hepatitis C virus (HCV) and Human Immunodeficiency virus (HIV) polymerases.
Due to his important antiviral activity, the crude methanolic stalk extract (89% of inhibition) was subjected to silica gel column chromatography to obtain eleven fractions (A-K). None of those fractions, tested at 50 μg/ml, was active against HCV and HIV polymerases but six fractions (B, C, D, E, I and J) were active against DEN and WN polymerases. These results were confirmed at lower concentration (10 μg/ml).

Keywords
Conyza canadensis
essentiel oil
antiviral activity
Manuscript
1 (3).pdf
Poster
1 (3).pdf
1 (3).pdf
Synthesis of some new diarylmethanes by McMurry coupling reaction: characterization and antibacterial activity
A review of some methods that incorporate decision-maker preferences in multi-objective evolutionary optimization using a multi-criteria classification method