Events 5th International Electronic Conference on Medicinal Chemistry

Event submissions

Published

10.3390/ECMC2019-06295

This submission belongs to the session A. ECMC-5 of the event 5th International Electronic Conference on Medicinal Chemistry

Published date

30 Oct, 2019

Citation

Ivan Nekrasa, Helen Bibik, Sergey Gennadievich Krivokolysko, Viktor Dotsenko, Konstantin Frolov, Aliona Startseva, Evaluation of the impact of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives on lepodova effects in the test of suspension by the tail, in Proceedings of 5th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2019, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2019-06295

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Evaluation of the impact of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives on lepodova effects in the test of suspension by the tail

Ivan Nekrasa ¹

Helen Bibik ²

Sergey Gennadievich Krivokolysko ³

Viktor Dotsenko ⁴

Konstantin Frolov ⁵

Aliona Startseva ⁶

1. "Lugansk state medical university named by Saint Luka", Assistant of Department of Fundamental and Clinical Pharmacology,.

2. "Lugansk state medical university named by Saint Luka", Professor, Head of the Department of Fundamental and Clinical Pharmacology.

3. "Lugansk state medical university named by Saint Luka", Professor, Head of the Department of Pharmaceutical Chemistry and Pharmacognosy.

4. FSBEI HE "Kuban State University", Professor, Head of the Department of Organic Chemistry and Technology.

5. "Lugansk state medical university named by Saint Luka", Associate Professor, Department of Pharmaceutical Chemistry and Pharmacognosy

6. "Lugansk state medical university named by Saint Luka"

Abstract

A series of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives exhibited high antidepressant and adaptogen activities. We now report a more detailed analysis of the effects of those substances on dopamine metabolism. For that purpose, we decided to unite two techniques: evaluation of the impact of compounds with antidepressant activity on levodopa effects and the test of suspension by the tail. Caffeine-sodium benzoate, amitriptyline, and fluoxetine were chosen as references.

Keywords

tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives

levodopa

suspension by the tail

amitriptyline

caffeine-sodium benzoate

fluoxetine.

Manuscript

EVALUATION OF THE IMPACT OF TETRAHYDROPYRIDO[2,1-B][1,3,5]THIADIAZINE DERIVATIVES ON LEPODOVA EFFECTS IN THE TEST OF SUSPENSION BY THE TAIL.pdf

Oral Presentation

EVALUATION OF THE IMPACT OF TETRAHYDROPYRIDO[2,1-B][1,3,5]THIADIAZINE DERIVATIVES ON LEPODOVA EFFECTS IN THE TEST OF SUS.pptx

Poster

EVALUATION OF THE IMPACT OF TETRAHYDROPYRIDO[2,1-B][1,3,5]THIADIAZINE DERIVATIVES ON LEPODOVA EFFECTS IN THE TEST OF SUS (presentation).pdf

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