EventsThe 23rd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-23-06479
This submission belongs to the session A. General Organic Synthesis of the event The 23rd International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2019
Citation
Isabel Garcia-Santos, Alfonso Castiñeiras, Nuria Fernández-Hermida, Lourdes Gómez-Rodríguez, Synthesis and characterization of some 5-acetylbarbituric based thiosemicarbazone derivatives., in Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-23-06479
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Synthesis and characterization of some 5-acetylbarbituric based thiosemicarbazone derivatives.

Isabel Garcia-Santos 1
Alfonso Castiñeiras 1
Nuria Fernández-Hermida 1
Lourdes Gómez-Rodríguez 1
1. Department of Inorganic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Abstract

A new series of 5-acetylbarbituric based thiosemicarbazones has been synthesized from 5-acetylbarbituric acid and unsubstituted/substituted thiosemicarbazides (1-6). The synthesized compounds were well characterized by elemental analyses, FT-IR, 1H, 13C NMR and mass spectroscopic methods. Three dimensional molecular structure of three compounds (1, 2 and 6) was determined by single crystal X-ray crystallography. The compounds were evaluated for their in vitro cytotoxicity against HeLa-229 cancer cell line.

Keywords
Thiosemicarbazones
5-acetylbarbituric acid
heterocyclics
single crystal
cytotoxicity
Manuscript
proceedings_ECSOC_23_sciforum-027731.pdf
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