Events The 23rd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session A. General Organic Synthesis of the event The 23rd International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2019

Citation

Anatoly Shutalev, Anastasia Fesenko, Ludmila Trafimova, Alexander Kuvakin, Maxim Zimin, A new efficient route to 2-alkylsemicarbazides, in Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-23-06501

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A new efficient route to 2-alkylsemicarbazides

Anastasia Fesenko ¹

Ludmila Trafimova ²

Maxim Zimin ²

Alexander Kuvakin ¹

Anatoly Shutalev ³

1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., 119991 Moscow, Russian Federation

2. Russian Technological University, 86 Vernadsky Avenue, 119571 Moscow, Russian Federation

3. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., 119991 Moscow, Russian Federation, Russia

Abstract

Synthesis of hardly available 2-alkylsemicarbazides and their hydrochlorides from semicarbazide hydrochloride has been developed. This general and efficient protocol is based on preparation of acetone semicarbazone, its N2-alkylation in the presence of sodium hydride, and hydrolysis under mild conditions.

Keywords

Semicarbazides

semicarbazones

alkylation

hydrolysis

Manuscript

Manuscript (sciforum-028154).pdf

Green, microwave-assisted synthesis of O-perbutirylated-alkyl-glycosides

VALIDATED STABILITY- INDICATING HPTLC METHOD FOR NINTEDANIB & CHARACTERIZATION OF DEGRADANTS BY LC-MSⁿ