EventsThe 23rd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-23-06607
This submission belongs to the session B. Bioorganic, Medicinal and Natural Products Chemistry of the event The 23rd International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2019
Citation
Mastoura Edrees, Sobhi M. Gomha, Zeinab A. Muhammad, Hatem M. Gaber, Mohamed M. Amin, Islam K. Matar, Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles, in Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-23-06607
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Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles

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Sobhi M. Gomha 1
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Mastoura Edrees 2
Zeinab A. Muhammad 3
Hatem M. Gaber 3
Mohamed M. Amin 4
Islam K. Matar 5
1. Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt
2. Department of Chemistry, Faculty of Science, king Khalid university, KSA, Saudi Arabia
3. National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Egypt
4. Department of Pharmacology, Medical Division, National Research Center,
5. Biomedical Sciences Department, University of Science & Technology, Zewail City of Science & Technology, Giza, 12588, Egypt
Abstract

Background: A novel series of fused imidazole was prepared from the reaction of 2- bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation. The structures of all the novel products were elucidated based on the elemental analysis and spectral data.

Results: In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti- ulcer agents.

Conclusion: The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.

Keywords
1
3
4-thiadiazoles
fused imidazoles
heterocyclic amines
microwave irradiation
anti-inflammatory
analgesic and anti-ulcer agents.
Manuscript
Manuscript.pdf
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