EventsThe 23rd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-23-06647
This submission belongs to the session A. General Organic Synthesis of the event The 23rd International Electronic Conference on Synthetic Organic Chemistry
Published date
15 Nov, 2019
Citation
Xiaoyun Hu, Jianxin Guo, Zhongyou Yin, Rui Zhang, Victor Borovkov, Asymmetric Biginelli-like reaction catalyzed by chiral TADDOL-derived phosphoric acid bearing two hydroxyl groups, in Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-23-06647
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Asymmetric Biginelli-like reaction catalyzed by chiral TADDOL-derived phosphoric acid bearing two hydroxyl groups

Jianxin Guo 1
Rui Zhang 1
Zhongyou Yin 1
Xiaoyun Hu 1
Victor Borovkov 1
1. South-Central University for Nationalities
Abstract

Several new chiral TADDOL-derived phosphoric acids bearing two hydroxyl groups have been successfully synthesized via highly regioselective 2,3-cyclosulfitation as asymmetric catalysts for Biginelli-like reaction. The obtained results clearly demonstrated that these catalysts are able to effectively catalyze the reactions with good to excellent enantioselectivities. A control experiment indicated that two hydroxyl groups are indispensable for high enantioselectivity of the Biginelli-like reaction.

Keywords
asymmetric Biginelli-like reaction
chiral phosphoric acids
regioselective 2,3-cyclosulfitation
Manuscript
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