EventsThe 23rd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-23-06657
This submission belongs to the session F. Ionic Liquids of the event The 23rd International Electronic Conference on Synthetic Organic Chemistry
Published date
16 Nov, 2019
Citation
Murali Venkata Basavanag Unnamatla, Erick Cuevas Yañez, Marco A García-Eleno, Ionic liquid mediated Ugi/SN₂ Cyclization: Synthesis of 1,2,3-Triazole containing novel 2,5-diketopiperazines., in Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-23-06657
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Ionic liquid mediated Ugi/SN2 Cyclization: Synthesis of 1,2,3-Triazole containing novel 2,5-diketopiperazines.

Murali Venkata Basavanag Unnamatla 1,2
Marco A García-Eleno 1,2
image
Erick Cuevas Yañez 1,2
1. Centro Conjunto de Investigacion en Química Sustentable UAEM-UNAM, Toluca, Estado de Mexico, Mexico.
2. Facultad de Quimica , Universidad Autonoma del Estado de Mexico
Abstract

The Ugi four-component reaction is versatile multicomponent reaction for generation of complex diversity, herein we used 4-((1-((tetrahydrofuran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde as one of the components in Ugi 4CR that contains 1,2,3- triazole moiety which is a privileged molecule in medicinal chemistry to obtain Ugi adducts under room temperature ionic liquids [BBIM]BF4 as medium of solvent, then followed SN2 pathway cyclization to get triazole containing 2,5-diketopiperazine derivatives in good yield using basic ionic liquids[BBIM]OH as a catalyst

Keywords
Ugi multicomponent reaction
Task-specific Ionic Liquid. 1,2,3 triazole
2,5-diketopiperazine.
Manuscript
Proceedings (1).pdf
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