The spatial and topological organization of cities have a great influence on the lives of their inhabitants, including mobility efficiency. Entropy has been largely adopted for the characterization of the most varied natural and human-made systems and structures. In this work, we apply entropy to characterize the uniformity of spatial coverage allowed by the geometry, reflected by the area, of city blocks. It is suggested that this measurement can predict several properties of real cities, such as mobility. We consider several real-world cities, from which the average minimal shortest path length is also calculated and compared with the entropy of the block areas. Several interesting results have been found and are discussed in the article.