EventsThe 23rd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-23-06700
This submission belongs to the session A. General Organic Synthesis of the event The 23rd International Electronic Conference on Synthetic Organic Chemistry
Published date
18 Nov, 2019
Citation
Sandra Cecilia Ramírez López, María del Rocio Gámez Montaño, Synthesis one pot of Alkyne-2-Chloroquinoline via a Passerini Reaction, in Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-23-06700
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Synthesis one pot of Alkyne-2-Chloroquinoline via a Passerini Reaction

Sandra Cecilia Ramírez López 1
María del Rocio Gámez Montaño 1
1. Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química
Abstract

A serie of six new alkyne-2-chloroquinoline were synthesized in moderate yields (40-65%) via the Passerini three-component reaction (P-3CR) under mild green conditions. The P-3CR take place when a carboxylic acid, an oxo compound (aldehydes or ketones) and an isocyanide reacted to give α-acyloxy carboxamides. Recently it has been reported that small molecules containing alkynes promote interactions with different proteins in cells facilitating the detection or identification of protein targets.

Keywords
Multicomponent reactions
Passerini reaction
2-chloroquinolin-3-carboxaldehyde
alkynes.
Manuscript
ID sciforum-028726 -Passerini.pdf
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