EventsThe 23rd International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-23-06704
This submission belongs to the session A. General Organic Synthesis of the event The 23rd International Electronic Conference on Synthetic Organic Chemistry
Published date
19 Nov, 2019
Citation
Mangesh Ghodke, Suvarna A. Wagh, Anna Pratima G. Nikalje, Julio A Seijas Vázquez, Ultrasound assisted synthesis of 2, 4-substituted 1, 5- benzothiazepine derivatives, in Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-23-06704
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Ultrasound assisted synthesis of 2, 4-substituted 1, 5- benzothiazepine derivatives

Mangesh Ghodke 1
Suvarna A. Wagh 2
image
Anna Pratima G. Nikalje 3
Julio A Seijas Vázquez 4
1. Department Of Pharmaceutical Chemistry, R. C. Patel Institute Of Pharmaceutical Education & Research, Shirpur-425405, Dhule (M.S.) India
2. MVP’s Institute of Pharmaceutical Sciences, Adgoan, Nashik-422003 (M.S.) India
3. Wilson college, Girgaon Chawpatty,Mumbai 400007 , Maharashtra, India
4. Departamento de Química Orgánica, Facultad de Ciencias, Universidad of Santiago De Compostela, Alfonso X el Sabio, Lugo 27002, Spain
Abstract

Abstract:A series of 15 novel derivatives of Synthesis of 2, 4-substituted 1, 5- benzothiazepine 5a–l were synthesized in good yield from the key compound 1, 3-substituted-prop-2-en-1-one (3a-l), called chalcone, with 2-aminothiophenol (0.01mol) and pinch of zirconium oxychloride and solvent dimethyl formamide (DMF), by using ultra-sonication as one of the green chemistry tools. All the synthesised compounds were evaluated for anticonvulsant activity. The synthesized derivatives were investigated for CNS depressant, maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (sc-PTZ) induced seizure and neurotoxicity screening.

Keywords
Green chemistry
ultra-sonication
Chalcone
Anticonvulsant
Manuscript
manuscript ECSOC.pdf
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