Peptide therapy reinforced with nanotechnology: an innovative strategy for controlled drug delivery

Recently, nanosciences have opened a large number of possibilities that contribute to finding timely solutions for multiple ailments; Cancer or Alzheimer's are being addressed with therapies that are based on focusing the treatment in a highly selective manner that guarantees greater efficacy in the dose and a prolonged effect. Peptide systems are designed from the specific characteristics of a certain pathology and have a molecular volume small enough to be produced in large quantities, while they are as evolved as high molecular weight molecules that can target and reduce the possibility of side effects.

However, in peptide therapies, it is a duel to deliver a peptide to the target, since in the course they are susceptible to being anabolized or they can accumulate in the surrounding tissue; These factors reduce the half-life of the treatment and impair its application for therapeutic purposes. This is precisely the reason why nanomaterials are presented as an alternative to create protection systems that offer them the resistance to reach their recognition cells.These vehicles have different natures and synthesis processes, but their purpose in essence is the same: "Increase the efficiency of drug administration". The most studied transporters include microemulsions, nanoparticles, hydrogels, encapsulations in: liposomes, micelles or polymers.

Next, its advantages and applications in systems coupled to peptides with therapeutic activity are described.