Events The 15th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 15th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2011

Citation

Sergey Gennadievich Krivokolysko, Victor Victorovich Dotsenko, Diversity-oriented Cascade Synthesis of Pyrido[2\',3\':4,5]thieno[2,3-b]pyridine Derivatives, in Proceedings of The 15th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2011, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-15-00727

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Diversity-oriented Cascade Synthesis of Pyrido[2\',3\':4,5]thieno[2,3-b]pyridine Derivatives

Sergey Gennadievich Krivokolysko ¹

Victor Victorovich Dotsenko ¹

1. ChemEx Laboratory, Vladimir Dal’ East Ukrainian National University, kv Molodezhny 20-A 7/309, 91034 Lugansk

Abstract

A library of 2-amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2\',3\':4,5]thieno[2,3-b]pyridines which recently have been reported as selective progesterone receptor agonists was synthesized by ternary condensation of N-methylmorpholinium 4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with malononitrile and acetone, and alternatively by reaction of bis(4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-yl)disulfides with acetone and malononitrile in basic media. The mechanism, scope and limitations of the reactions are discussed.

Keywords

dipyridothiophenes

thienopyridines

progesterone receptor agonists

cascade heterocyclization

Influence of the substitution on the inversion barrier of corannulene: a theoretical study.

Synthesis of new bitopic tetra(pyrazolyl)-ligands with neopentane and o-xylene backbones