Colchicine plus fosfomycin in coronavirus infection

Some antibiotics can act as immunomodulators and particularly fosfomycin has an
immunomodulatory effect on human B-cell activation. Fosfomycin is considered a unique
antibiotic that is chemically unrelated to any other known antibacterial agent. The effect of
fosfomycin on human T-cells function was yet studied and the inhibition of proliferation of human lymphocytes induced by polyclonal T-cell mitogens was studied as a function of fosfomycin dose.
It was also described the suppression by fosfomycin of mixed lymphocyte reaction and
interleukin-2 (IL-2) production by T cells along with the expression of IL-2 receptor (CD25) on the activated T-cell surfaces.

Previous research demonstrated that fosfomycin blocks T-cell division during the transition from G1 to S phase of the cell cycle.

The effect of oral colchicine on T cell subsets, monocytes and concanavalin A‐induced
suppressor cell function in asthmatic patients was studied by Dr D. N. Ilfeld (Institute of
Pulmonary Diseases and Clinical Pharmacology Unit, Beilinson Medical Center, Petah Tikva;
Department of Cell Biology, Weizmann Institute of Science, Rehovot; Clinical Immunology
Laboratory, Soroka Medical Center, Beer Sheva, Israel) and found that asthmatic patients have a deficiency of concanavalin A‐(Con A) induced suppressor cell function, which can be corrected by using colchicine regime of oral colchicine 0·5 mg twice daily for 7 days .