Event submissions
Published
This submission belongs to the session H. Round Table on Parasitic Diseases of the event 6th International Electronic Conference on Medicinal Chemistry
Published date
06 Nov, 2020
Citation
Douglas Chaves de Alcantara Pinto, Paulo Pitasse Santos, Afonso Santine Magalhães Mesquita-Velez, Gabriella Calheiros Magalhães, Debora Decoté Ricardo, Marco Edilson Freire de Lima, Design and synthesis of novel alfa-mangostin-nitroimidazole hybrids with toxic effects on amastigotes of Trypanosoma cruzi, in Proceedings of 6th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2020, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2020-07434
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Design and synthesis of novel alfa-mangostin-nitroimidazole hybrids with toxic effects on amastigotes of Trypanosoma cruzi
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Douglas Chaves de Alcantara Pinto 1
Paulo Pitasse Santos 1
Afonso Santine Magalhães Mesquita-Velez 1
Gabriella Calheiros Magalhães 1
Debora Decoté Ricardo 1
Marco Edilson Freire de Lima 1
1. Universidade Federal Rural do Rio de Janeiro
Abstract
alfa-Mangostin (MGT) is the main product isolated from the the fruit pericarp of Garcinia mangostana. This xanthone exhibits important toxic effects on T. cruzi forms amastigotes. We describe herein the synthesis of new hybrid derivatives of MGT and nitroimidazoles using click reaction as the key-step. Toxic effects on intracellular amastigotes of T. cruzi (Tulahuen C2C4 LacZ).
Keywords
antiparasitic chemotherapy
Chagas disease
click reaction
Garcinia mangostana
molecular hybridization
Oral Presentation
Presentation Electronic_Conference_on_Medicinal_Chemistry_2020_.pptx
Poster
Presentation Electronic_Conference_on_Medicinal_Chemistry_2020_.pdf
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