Events6th International Electronic Conference on Medicinal Chemistry
Event submissions
Published
with-doi10.3390/ECMC2020-07463
This submission belongs to the session C. General: Presentations of the event 6th International Electronic Conference on Medicinal Chemistry
Published date
06 Nov, 2020
Citation
Krzysztof Siczek, Przemyslaw Kubiak, Justyn Ochocki, Prevention of the probe hole clogging up during administration of nano Ag preparations in animal models of gastrointestinal diseases, in Proceedings of 6th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2020, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2020-07463
Share
Email
Facebook
Twitter
LinkedIn

Prevention of the probe hole clogging up during administration of nano Ag preparations in animal models of gastrointestinal diseases

Krzysztof Siczek 1
Przemyslaw Kubiak 2
Justyn Ochocki 3
1. Department of Vehicles and Fundamentals of Machine Design, Lodz University of Technology, Poland, Stefanowskiego Str. 1/15, 90-537 Lodz, Poland, Poland
2. Institute of Vehicles and Construction Machinery Engineering, Warsaw University of Technology, Poland, Narbutta Str. 84, 02-524 Warsaw, Poland
3. Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszynskiego Str. 1, 90-151 Lodz, Poland
Abstract

The present study concerns the resistance to motion of syringe plunger against syringe barrel during intragastrical administration of silver preparations into mice models of gastrointestinal diseases. The mathematical model of drug flow in the syringe barrel-hub-needle assembly was elaborated and presented. The effect of geometrical parameters of the mentioned assembly affecting the resistance to motion was profoundly investigated. The resistance to motion during administration of silver preparation depended mainly on the needle hole diameters and hub hole. The form of silver preparation and length of needle only slightly affected the resistance to motion. The important role of albumin in prevention of Ag nanoparticles agglomeration was found.

Keywords
Ag preparations
animal model
anti-clogging
gastrointestinal tract
Oral Presentation
2020-Electronic_Conference_on_Medicinal_Chemistry_PPT_KSPKJO.pptx
Poster
2020-Electronic_Conference_on_Medicinal_Chemistry_PPT_KSPKJO.pdf
2020-Electronic_Conference_on_Medicinal_Chemistry_PPT_KSPKJO.pdf
(1R, 2R, 6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol derivatives as promising compounds for anti-Parkinsonian activity
New sulfonates and amides derived from berberine as Tdp1 inhibitors