EventsThe 15th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-15-00770
This submission belongs to the session a. General Organic Synthesis of the event The 15th International Electronic Conference on Synthetic Organic Chemistry
Published date
31 Oct, 2011
Citation
Mojtaba Azimoshan, Mohammad G. Dekamin, Facile and One- pot synthesis of α- Amino Nitriles by Strecker Reaction Catalyzed by {[Bmim] PINO}as a New Ionic Liquid, in Proceedings of The 15th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2011, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-15-00770
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Facile and One- pot synthesis of α- Amino Nitriles by Strecker Reaction Catalyzed by {[Bmim] PINO}as a New Ionic Liquid

Mojtaba Azimoshan 1
Mohammad G. Dekamin 1
1. Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran
Abstract
A simple, convenient, and practical method for the synthesis of α-amino nitriles through a one-pot, three-component Strecker reaction of diverse carbonyl compounds and amines with trimethylsilyl cyanide (TMSCN) under mild conditions in EtOH 96 % has been developed. Reactions proceed efficiently in the presence of a catalytic amounts of new and recoverable ionic liquid of N-butyl-N-methyl imidazolium Phthalimide-N-Oxyl {[Bmim] PINO} at room temperature.
Keywords
α-amino nitriles
Multi-component Reactions (MCRs)
Strecker reaction
IOnic Liquids
N-butyl-N-methyl imidazolium Phthalimide-N-Oxyl {[Bmim] PINO}
Nano-Ordered MCM-41-SO3H as a Heterogeneous and Efficient Catalyst for Synthesis of Bis(indolyl)methanes Under Solvent-Free Conditions
Substituent Effect on the Aromaticity of 1,3-Azole Systems