Events The 24th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session A. General Organic Synthesis of the event The 24th International Electronic Conference on Synthetic Organic Chemistry

Published date

13 Nov, 2020

Citation

Victor V Dotsenko, Dmitry T. Tebiev, Diana D. Guz', Nicolai A. Aksenov, Inna V. Aksenova, A new approach to 7-amino-4-oxo-4,5-dihydro-3H-pyrano[2,3-d]pyrimidine-6-carbonitriles, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08105

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A new approach to 7-amino-4-oxo-4,5-dihydro-3H-pyrano[2,3-d]pyrimidine-6-carbonitriles

Dmitry T. Tebiev ¹

Diana D. Guz' ¹

Victor V Dotsenko ^2,3,4

Nicolai A. Aksenov ⁴

Inna V. Aksenova ⁴

1. Kuban State University

2. Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya Str., 350040 Krasnodar, Russia

3. ChemEx Lab, Vladimir Dal’ Lugansk National University

4. North Caucasus Federal University

Abstract

S-alkyl derivatives of thiobarbituric acid easily react with arylmethylene malononitriles in the presence of base to give new 7-amino-4-oxo-4,5-dihydro-3H-pyrano[2,3-d]pyrimidine-6-carbonitriles. The structure of products and the mechanism of formation are discussed.

Keywords

Thiobarbituric acid

malononitrile

2-amino-4H-pyran-3-carbonitriles

Michael addition

heterocycliaztion

Manuscript

sciforum-040074.pdf

Synthesis and quantum-chemical studies of new hybrid heterocyclic molecules derived from 3-(thiocyanatoacetyl)coumarin

A simple and sustainable synthetic lab-protocol for obtaining racemic dominicalure- aggregation pheromone of the grain beetle Rhyzopertha dominica F. (Coleoptera, Bostrichidae)