EventsThe 24th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-24-08296
This submission belongs to the session B. Bioorganic, Medicinal and Natural Products Chemistry of the event The 24th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2020
Citation
Sandeep Waghulde, Omkar Dukare, Harshada More, Aaditi Pacharkar, Prajwal Gharat, Deepak Gupta, Nilesh Gorde, Ajay Kharche, Mohan Kale, Evaluation of Phytochemical & Antimitotic Potential of Annona Reticulata extracts by Onion root model, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08296
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Evaluation of Phytochemical & Antimitotic Potential of Annona Reticulata extracts by Onion root model

Sandeep Waghulde 1
Omkar Dukare 2
Harshada More 2
Aaditi Pacharkar 2
Prajwal Gharat 2
Deepak Gupta 2
Nilesh Gorde 3
Ajay Kharche 4
Mohan Kale 5
1. Research Student, Hon’ble Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Dist: Jalgaon; Maharashtra, India
2. Research Student, Department of Pharmaceutical Chemistry, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, University of Mumbai, Maharashtra, India
3. Assistant Professor, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Dist-Raigad University of Mumbai
4. Assistant Professor, Department of Pharmaceutical Chemistry, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, University of Mumbai, Maharashtra, India
5. Principal & Professor, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Dist-Raigad University of Mumbai
Abstract

This study investigated phytochemial investigation and extraction methods with polar and non polar solvent which could be used to compare and see the effectiveness of each on the chromosomes. The FTIR spectrum shows the presence of acetogenins in the extracts. Cytotoxic effects were studied using Allium cepa root tip cells. Eight onion bulbs were subjected to the treatment groups which were made using water, methanol, Ethyl acetate, acetone and hexane extracts of A. reticulata. Three different concentrations from each extraction solvent were used. The A. cepa root tip cells were subjected for 24 h to three different leaf extractions after left to grow in water. Concentrations of 0.1, 1, 10 and 50 mg/L were used. All studied concentrations of A. reticulata methanol extract showed significant (p˂0.05) drop in the mean mitotic index when compared with control Overall decrease in MI was contributed to by all the stages of mitosis.

Keywords
Annona reticulate
antimitotic potential
A. cepa root tip
Phytochemical Analysis
acetogenins
Manuscript
sciforum-038504.pdf
Photosynthesis-Inhibiting Activity of Methoxy-substituted 3-Hydroxynaphthalene-2-carboxanilides
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