EventsThe 24th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-24-08297
This submission belongs to the session B. Bioorganic, Medicinal and Natural Products Chemistry of the event The 24th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2020
Citation
Sandeep Waghulde, Tushar Baviskar, Praful Patil, Shweta Singh, Nilesh Gorde, Mohan Kale, Vijay R. Patil, Ajay Kharche, Cumulative Cytotoxicity Assay of the Aqueous and Ethanolic Extracts of the Selected Medicinal Plants using Crown Gall Tumor Disc Bioassay, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08297
Share
Email
Facebook
Twitter
LinkedIn

Cumulative Cytotoxicity Assay of the Aqueous and Ethanolic Extracts of the Selected Medicinal Plants using Crown Gall Tumor Disc Bioassay

Sandeep Waghulde 1
Tushar Baviskar 2
Praful Patil 2
Shweta Singh 2
Nilesh Gorde 3
Mohan Kale 4
Vijay R. Patil 5
Ajay Kharche 6
1. Research Student, Hon’ble Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Dist: Jalgaon; Maharashtra, India
2. Research Student, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Raigad, India
3. Assistant Professor, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Dist-Raigad University of Mumbai
4. Principal & Professor, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Dist-Raigad University of Mumbai
5. Principal and Professor, Hon'ble Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Dist: Jalgaon
6. Assistant Professor, Department of Pharmaceutical Chemistry, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, University of Mumbai, Maharashtra, India
Abstract

The present study was conducted to test for in vivo crown gall tumor disc bioassay using potato discs of the aqueous and ethanolic extracts of Annona reticulata with Allium sativum, Allium fistolisum Brassica oleraceae and correlate cytotoxicity results with known pharmacological activities of the plants. Cytotoxicity was evaluated in terms of Crown Gall Tumor Disc Bioassay. The use of highly specific, quantitative bioassays which require only a short period of time to obtain results are available for studying crown gall tumor formation. Results showed that the extracts of Annona reticulata with Allium sativum, Allium fistolisum and Brassica oleraceae were potent against the Crown Gall Tumor Disc Bioassay when compared alone with combined extracts. It indicated that bioactive components are present in these plants that could be accounted for its pharmacological effects. Thus, the results support the uses of these plant species in traditional medicine.

Keywords
Crown Gall Tumor Disc Bioassay
Annona reticulate
Allium sativum
Allium fistolisum
Brassica oleraceae
potato disc bioassay
antitumour
cytotoxicity
Manuscript
sciforum-038505.pdf
Evaluation of Phytochemical & Antimitotic Potential of Annona Reticulata extracts by Onion root model
Study of ADMET Descriptors of Novel Chlorinated N-Arylcinnamamides