Events The 24th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session A. General Organic Synthesis of the event The 24th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2020

Citation

Victor V Dotsenko, Alexandra R. Chikava, Alexey A. Dolganov, On the acylation of 1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08315

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On the acylation of 1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles

Alexandra R. Chikava ¹

Alexey A. Dolganov ¹

Victor V Dotsenko ^2,3,4

1. Kuban State University

2. Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya Str., 350040 Krasnodar, Russia

3. ChemEx Lab, Vladimir Dal’ Lugansk National University

4. North Caucasus Federal University

Abstract

1,6-Diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles, prepared by reaction of cyanoacethydrazide with arylmethylene malononitriles, react with 1-cyanoacetyl-3,5-dimethylpyrazole and chloroacetyl chloride to give corresponding cyanoacetamides and chloroacetamides. The reaction with phthalic anhydride proceed under harsh conditions to give 4,7-dioxo-4,7-dihydropyrido[1',2':2,3][1,2,4]triazolo[5,1-a]isoindole-1,3-dicarbonitriles.

Keywords

cyanoacethydrazide

N-aminopyridines

cyanoacetylation

heterocyclization

Manuscript

sciforum-039158-j.pdf

Direct arylation-based synthesis of carbazoles using an efficient palladium nanocatalyst under microwave irradiation

Microwave-assisted Asinger synthesis of thiazolines