Microwave assisted facile synthesis and anticancer evaluation of new substituted-3-methyl-1- substituted phenyl-1H-pyrazole

Herewith, we report the design and synthesis of a series of the cyclo-condensation of the substituted hydrazine derivatives with the substituted 1,3-dicarbonyl compound is a simple and rapid approach to obtain substituted pyrazoles. This compound was obtained by using zinc oxide as catalyst and water as a solvent under microwave irradiation for about 12-14 min (450 W) at 90⁰C to get structural prerequisite indispensable for anticancer activity. The synthesized derivatives were investigated for MTT assay, enzymatic assay and molecular modeling studies. Most of the compounds were found to be potent in anticancer evaluation.