Events The 24th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session A. General Organic Synthesis of the event The 24th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2020

Citation

Victor V Dotsenko, Alena Russkih, Nicolai Aksenov, Synthesis of new 2-oxonicotinic acids, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08365

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Synthesis of new 2-oxonicotinic acids

Victor V Dotsenko ^1,2,3

Alena Russkih ⁴

Nicolai Aksenov ³

1. Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya Str., 350040 Krasnodar, Russia

2. ChemEx Lab, Vladimir Dal’ Lugansk National University

3. North Caucasus Federal University

4. Kuban State University

Abstract

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by ternary condensation of Meldrum’s acid with triethyl orthoformate and aniline, reacts with N-aryl cyanoacetamides in the presence of KOH to give 2-oxo-1,2-dihydropyridine-3-carboxylic acids, which are useful as drug precursors or perspective ligands.

Keywords

nicotinic acids

Meldrum’s acid

2-oxo-1,2-dihydropyridine-3-carboxylic acid

cyanoacetamides

Manuscript

GeneralOrganicSynthesis_8365_Synthesis_of_new_2_oxonicotini_done.pdf

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