Efficient Multicomponents Catalyst-free Synthesis of substituted 2-aminopyridines

2-Aminopyridines scaffolds are an important class of nitrogen heterocyclic compounds with a wide range of biological activities^1-2 (Figure 1). Multicomponent reactions (MCRs) are useful method for the construction of nitrogen heterocyclic compounds. In this context, syntheses of 2-aminopyridines derivatives via MCRs have attracted considerable attentions in recent years^3-4.

We present, in this work, a rapid and efficient synthesis of 2-aminopyridines derivatives, via catalyst-free four-component method. This protocol provides a simple and practical approach to functionalized 2-aminopyridnes from readily available substrates under solvent free conditions.