Events The 24th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session A. General Organic Synthesis of the event The 24th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2020

Citation

Erick Cuevas-Yañez, Josué Varela-Palma, Jaime González, Gustavo Lopez-Téllez, M. V. Basavanag Unnamatla, Marco A. García-Eleno, Synthesis of 1,2,3-triazoles from alkyne-azide cycloaddition catalyzed by a bio-reduced alkynylcopper (I) complex, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08384

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Synthesis of 1,2,3-triazoles from alkyne-azide cycloaddition catalyzed by a bio-reduced alkynylcopper (I) complex

Josué Varela-Palma ¹

Jaime González ¹

Gustavo Lopez-Téllez ¹

M. V. Basavanag Unnamatla ¹

Marco A. García-Eleno ¹

Erick Cuevas-Yañez ^1,2

1. Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco Km. 14.5, Toluca, Estado de México 50200, Mexico

2. Facultad de Química, Facultad de Química, Universidad Autónoma del Estado de México. Paseo Colón esq. Paseo Tollocan, 50120, Toluca, Mexico

Abstract

A small library of 1,2,3-triazoles was synthesized from diverse alkynes and azides using catalytic amounts of an alkynylcopper (I) complex which in turn was prepared from direct treatment of phenylacetylene with Fehling reagent in presence of glucose as reducing agent. The results suggest that CuAAC reaction requires only 0.5 mg/mmol copper (I) phenylacetylide without any further additives.

Keywords

1,2,3-triazole

alkynylcopper(I) complex

click chemistry

bio-reduced catalyst

Manuscript

GeneralOrganicSynthesis_8384_Synthesis_of_1_2_3_triazoles_f_done.pdf

Oral Presentation

alkynyl_2nov2020.pptx

Evaluation of fluorescent staining capacity of two New Nile Blue analogues

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