Events The 24th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session A. General Organic Synthesis of the event The 24th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2020

Citation

Victor V Dotsenko, Aminat M. Semenova, Nicolai Aksenov, New reactions of 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08398

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New reactions of 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile

Victor V Dotsenko ^1,2,3

Aminat M. Semenova ^4,5

Nicolai Aksenov ³

1. Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya Str., 350040 Krasnodar, Russia

2. ChemEx Lab, Vladimir Dal’ Lugansk National University

3. North Caucasus Federal University

4. Kuban State University

5. North-Caucasus State Humanitarian Technological Academy, 36 Stavropolskaya St., Cherkessk 369000, Karachay-Cherkess Republic, Russia

Abstract

5-Amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, prepared by reaction of malononitrile dimer with hydrazine, smoothly react with chloroacetyl chloride to afford 2-chloro-N-(4-cyano-3-(cyanomethyl)-1H-pyrazol-5-yl)acetamide in good yield. The latter easily react with 3-cyanopyridine-2-thiolates to give hybrid molecules bearing nicotinonitrile and pyrazole units.

Keywords

malononitrile dimer

heterocyclization

cyanomethylpyrazole

S-alkylation

Thorpe-Ziegler reaction

Manuscript

GeneralOrganicSynthesis_8398_New_reactions_of_5_amino_3_cy_original-done.pdf

Synthesis of new water-soluble Bunte salts bearing thieno[2,3-b]pyridine-3-yl substituents

The reactions of N,N'-diphenyldithiomalonamide with Michael acceptors