EventsThe 24th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-24-08423
This submission belongs to the session A. General Organic Synthesis of the event The 24th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2020
Citation
Vanessa Gomes, João Ferreira, Renato Boto, Paulo Almeida, Maria João Sousa, Lucinda Reis, Maria Sameiro, Two symmetrical squarylium cyanine dyes: synthesis, photophysics and antifungal activity in Saccharomyces cerevisiae, in Proceedings of The 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-24-08423
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Two symmetrical squarylium cyanine dyes: synthesis, photophysics and antifungal activity in Saccharomyces cerevisiae

Vanessa Gomes 1
João Ferreira 2
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Renato Boto 3
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Paulo Almeida 4
Maria João Sousa 5
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Lucinda Reis 6
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Maria Sameiro 7
1. Chemistry Centre of Vila Real (CQ-VR) / Chemistry Department, University of Trás-os-Montes and Alto Douro Centre of Chemistry (CQ-UM) / Department of Chemistry, University of Minho, Portugal
2. Centre of Chemistry (CQ-UM) / Department of Chemistry, University of Minho Centre of Molecular and Environmental Biology (CBMA) / Department of Biology, University of Minho
3. Health Sciences Research Centre (CICS-UBI) Chemistry Department University of Beira Interior
4. Health Sciences Research Centre (CICS-UBI) / Chemistry Department University of Beira Interior
5. Centre of Molecular and Environmental Biology (CBMA) / Department of Biology, University of Minho Institute of Science and Innovation for Bio-Sustainability (IBS), University of Minho
6. Chemistry Centre of Vila Real (CQ-VR) / Chemistry Department
7. Centre of Chemistry (CQ-UM) / Department of Chemistry, University of Minho
Abstract

Squarylium cyanine dyes are compounds 1,3-disubstituted that have a central four-carbon ring, derived from squaric acid, attached to aromatic or heterocyclic rings. These compounds have a zwiteronic structure, that typically absorbs in the visible to near-infrared region and, normally, present high molar absorption coefficient, high photochemical stability, and good photoconductivity. Considering these properties and depending on the potential application of this class of compounds, changes in their structure can be made.
In this work, two squarylium cyanine dyes were synthesized and characterized by the usual analytical techniques, including by UV-Vis-NIR absorption and emission spectroscopy. Their antifungal activity was evaluated, through the obtention of MIC values, using yeasts of the species Saccharomyces cerevisiae as a biological model and the results will be presented.

Keywords
Squaraine dyes
antifungal activity
Manuscript
GeneralOrganicSynthesis_8423-done.pdf
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