Inclusion Complex of Iloperidone with sulfobutyl ether beta-cyclodextrin: Characterization and dissolution studies

Iloperidone (Ilo) is a second-generation antipsychotic drug, is the first-line treatment, and approved by USFDA in May 2009. Iloperidone belongs to Biopharmaceutical Classification Systems (BCS) class II; thus, it is poorly water-soluble, highly permeable, and has pH-dependent solubility. Cyclodextrins and its derivatives have a wide range of applications in different formulations due to their complexation ability, which improves the solubility, stability, safety, and bioavailability of a drug. We have tried the complexation of iloperidone with sulfobutyl ether-β-cyclodextrin (SEβCD) with the aim of improving its solubility and dissolution. Complexation was done by the kneading method. Characterization of SEβCD complexes with Iloperidone was done by FTIR, DSC, saturation solubility, etc. Multimedia dissolution of the complex was carried out and compared with the plain drug. Significant improvement in drug release was found from SEβCD complexes in all media when compared with drug alone.

Acknowledgment

This research was supported by the Science and Engineering Research Board, File Number: CRG/2018/003176. The authors would like to acknowledge the help provided by Cyclolab in the form of gift sample of SEBCD.