Electrospinning of biomolecules and cell-derived bodies

Increasingly, the most potent emerging medicines are based not on small-molecule active ingredients but instead on large biomolecules such as peptides and proteins, or even on cells and sub-cellular components. These are difficult to process using traditional pharmaceutical processing approaches because their three-dimension tertiary structure is easily degraded, for instance by the application of heat in spray drying. Since electrospinning avoids the use of heat, it offers a potential route to develop stable and potent medicines from these active ingredients. This presentation will describe recent results in the production of electrospun formulations of protein drugs and extracellular vesicles.