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This work compares the oxidative stability of two margarines with vegetable oils of equal composition in both saturated and unsaturated fatty acids. For this purpose, weighted averages of the composition of the oils are calculated and their induction times at 1200C were previously computed by QSPR. The results obtained from this calculation are compared to those obtained for equal weight of margarine in Rancimat at the same temperature. These results show that margarines have lower oxidative stability than oils with the same composition in fatty acids, which is explained by the fact that the presence of water in margarines generates hydrolysis reactions that speed up the oxidative process.