Cyclodextrins in traditional and alternative drug formulations

Introduction

Cyclodextrins (CDs) have a wide range of applications in different field of drug formulation due to their complexation ability which could improve the solubility, stability, safety and bioavailability of drug molecules. The application of natural and chemically modified CDs could present inclusion complexes by different technological methods. CDs are able to extend the function of pharmaceutical additives therefore their application become effective and valuable tool for development of drug delivery systems during different administration routes. Our research interest focused on the development of preparation protocols using cyclodextrins combined with other additives to produce suitable formulations (to reach local or systemic effect) to get effective therapies in different diseases.

Materials and methods

Niflumic acid, Levodopa, and Ciprofloxacin were used as a model active ingredients for preparation of samples could be used by per os, intranasal and pulmonary application. α-, β-, HPβCD and different kind of polymer as stabilizer (PVA, PVP) were also applied. Samples were produced by kneading, solvent evaporation, co-grinding and spray drying technologies. The particle size distribution and morphology were determined with laser diffraction and scanning electron microscopy. The surface adhesion was analyzed using contact angle system. Physico-chemical properties analyzed with differential scanning calorimetry and X-ray powder diffraction. In vitro drug release was carried out by modified paddle method in different media. Aerodynamic properties have been tested in vitro using Cascade Impactor. A modified horizontal diffusion cell was used by the in vitro penetration test.

Results and discussion

The presentation will introduce case studies our applied material- and technological parameters during the preformulation of samples containing model drugs, CD and other additives. Per os, intranasal and pulmonar formulation aspects of prepared systems will be also summarized focusing on structural, micrometric and in vitro investigations.

Acknowledgement: This work was supported by the Ministry of Human Capacities, Hungary grant (20391- 3/2018/FEKUSTRAT) and 2.2.1-15-2016-00007 Project