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This study aimed to evaluate the changes in the health-related quality of life of immigrant Chinese women in Japan following the COVID-19 outbreaks. We conducted a paper questionnaire survey and an electronic questionnaire survey before and after the COVID-19 outbreak. HRQOL was evaluated using the 36-Item Short-Form Health Survey version 2.0. The women showed a high impaired risk of functioning due to mental health problems and presented a decreased impaired risk of the physical health-related domain. The women demonstrated poor mental health, but emergency prevention measures have given them a chance to rest and improve their physical health.