EventsMOL2NET'20, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 6th ed.
Event submissions
Published
with-doi10.3390/mol2net-06-09175 (registering DOI)
This submission belongs to the session 01. CHEMBIOMOL-06: Chem. Biol. & Med. Chem. Workshop, Bilbao-Rostock, Germany-Galveston, Texas, USA, 2020 of the event MOL2NET'20, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 6th ed.
Published date
15 Jan, 2021
Citation
Carlos Santiago, Nuria Sotomayor, Esther Lete, Site Selective Monoacylation of Pyrroles through Palladium-Catalyzed C-H Activation with Aldehydes. Synthesis of Pyrrolomycins, in Proceedings of MOL2NET'20, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 6th ed., 30 January 2020–30 January 2021, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-06-09175
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Site Selective Monoacylation of Pyrroles through Palladium-Catalyzed C-H Activation with Aldehydes. Synthesis of Pyrrolomycins

Carlos Santiago 1
Nuria Sotomayor 1
Esther Lete 1
1. Departamento de Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, Universidad del País Vasco / Euskal Herriko Unibertsitatea UPV/EHU, Apdo. 644, 48080, Bilbao, Spain.
Abstract

Site selective monoacylation of pyrroles has been achieved via Pd(II)-catalyzed C-H activiation with aldehydes in the presence of TBHP as oxidant using the 3-methyl-2-pyridine as directing group. The reaction has been extended to different aromatic and heteroaromatic aldehydes for the synthesis of a series of di(hetero)aryl ketones. The utility of the methodloogy has been demonstrated in the synthesis of pyrrolomycins, as Celastramycin analogues and Tolmetin.

Keywords
Organic chemistry
Palladium
Pyrrolomicyns
Pyrroles
Manuscript
Mole2Net 2020 Carlos Santiago 15012021.pdf
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