EventsThe 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response
Event submissions
Published
with-doi10.3390/IECC2021-09215
This submission belongs to the session 8. Poster of the event The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response
Published date
29 Jan, 2021
Citation
Douglas Vieira Thomaz, Pierre Alexandre dos Santos, Electrochemical behavior of Methotrexate upon binding to the DNA of different cell lines, in Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response, 1 February–14 February 2021, MDPI: Basel, Switzerland, doi: 10.3390/IECC2021-09215
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Electrochemical behavior of Methotrexate upon binding to the DNA of different cell lines

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Douglas Vieira Thomaz 1
Pierre Alexandre dos Santos 2
1. Università del Salento, Brazil
2. Federal University of Goiás
Abstract

Methotrexate (MTX) is a widely used anticancer agent whose DNA binding properties are well known. Despite its consolidated usage in the therapeutics of cancer, the physicochemical features of MTX binding to healthy and neoplastic DNA are still not fully understood. Therefore, this work showcases the electrochemical study of MTX binding to distinct DNA sequences through voltametric approaches.

Keywords
antineoplastic
in silico
molecular docking
diffusion coefficient
voltammetry
Manuscript
sciforum-042379.pdf
Poster
sciforum-042379.pdf
sciforum-042379.pdf
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