EFFICIENT SYNTHESIS OF DHA TRANSITION METAL CHELATES AS POTENT ANTIOXIDANTS, ENZYM INHIBITOR AND ANTIMICROBIAL AGENTS.

There is a growing interest on DHA derivatives compounds in recent years, due to an establish antibacterial, antifungal, anti-inflammatory and anticancer activities, several researches were performed on ligand precursor and transition metal complexes derivatives. [1,4]

Efficient and easy access to different classes family using dehydroacetic acid DHA as starting materials is reported, the obtained compounds were fully characterized by UV-Vis and FT-IR spectroscopy in addition to X ray diffraction on monocristal, several in vitro biological tests were also performed on this metal chelates to explore its therapeutically potential in order to continue further investigations and exploring them as new target drugs. In this case, antioxidant activities: ATBS, B-carotene, Metal chelate essays CCA and Fe⁺⁺, enzymatic activity: urease inhibitors and antimicrobial activity against several bacterial and fungal referenced strains, exhibit interesting results which will be developed in this work .