UHPLC-HRMS analysis of Coccoloba cowellii, an endemic endangered plant from Cuba

Coccoloba cowellii Britton (Polygonaceae) is an endemic and critically endangered plant that only grows in Camagüey, province of Cuba. In this study a total of 13 compounds were identified in a methanolic leaf extract, employing a dereplication of the UHPLC-HRMS data by means of Feature-Based Molecular Networking (FBMN) analysis in the Global Natural Products Social Molecular (GNPS) Network, together with the results obtained from the MS-DIAL software, the interpretation of the MS/MS data and comparison with the literature. The major constituents were glucuronides and glycosides of myricetin and quercetin, as well as epichatechin-3-O-gallate, catechin, epicatechin and gallic acid, all of them being reported for the first time in C. cowellii leaves. The constituents identified highlight the potential of C. cowellii leaves, increasing the interest in the implementation of conservation strategies for this endangered species.