The virus is a microorganism that uses the machinery of the host to multiply. At present, there are various species of viruses known to us that are dangerous for the health of human beings. One of such viruses has destroyed many lives nowadays and that is a coronavirus. Such other viruses like Human Immunodeficiency Virus, Poliovirus, etc. destroy one’s capability to survive normally. As science progresses, we invent many antiviral drugs as per the type of virus. There are many antiviral drugs available to treat viral infections. From them, benzothiazole derivatives are potent antiviral agents. Researchers continuously work on benzothiazole moiety to get more effective benzothiazole derivatives that can be used as antiviral agents. This review article gives information about various benzothiazole derivatives that act against the various viruses as antiviral agents, the structure-activity relationship of benzothiazole as an antiviral agent, various schemes to synthesize benzothiazole derivatives as an antiviral agent as well as includes various methods to evaluate the antiviral activity of novel synthetic compounds against specific viruses.