In vitro DNA damage protection activity of four novel bridged dinuclear cis- and transplatin-L-Zn(terpy) complexes

¹ State University of Novi Pazar, Department of Natural-Mathematical Sciences, Vuka Karadžića 9, 36300 Novi Pazar, Serbia
² University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijića bb, 34000 Kragujevac, Serbia
³ Academy of Professional Studies Šumadija, Department in Kruševac, Kosančićeva 36, 37000 Kruševac, Serbia

Academic Editor: Jean Jacques Vanden Eynde

Published: 03 November 2021 by MDPI in 7th International Electronic Conference on Medicinal Chemistry session General

https://doi.org/10.3390/ECMC2021-11511

Abstract:

For investigation of in vitro DNA damage protection activity four novel dinucler cis- and transplatin-L-Zn(terpy), where bridging ligand L = pyrazine or 4,4’-bipyridyl, were synthesized. DNA protective effect of the complexes at various concentrations (25, 50, 100, 200 and 400 μg/mL) against the hydroxyl and peroxyl radicals-induced DNA damage were determined using two different in vitro antioxidant assays. Dinuclear complexes exhibited moderate to high DNA-protective effects which depend on the geometry of [PtCl₂(NH₃)₂] complexes as well as the type of the bridging ligand.

Keywords: cisplatin; transplatin, Zn(terpy) complexes; DNA damage; hydroxyl radical; peroxyl radical

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