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Aerobic and biomimetic activation of C-H bonds of phenols catalyzed by copper-amine complexes
Mebrouka Dekhici
1
,
*
2
,
2
,
Nawel Cheikh
1, 3
Academic Editor: Julio A. Seijas
Published:
13 November 2021
by MDPI
in The 25th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
https://doi.org/10.3390/ecsoc-25-11674
(registering DOI)
Abstract:
Various copper complexes were prepared (CuCl(phen), Cucl(bipy), CuCl(neocu), CuCl(BPA), [CuCl(OH)(tmeda)]2 ) and tested in aerobic room temperature oxidation of p-cresol. The complexe [CuCl(OH)(tmeda)]2 was found has the more efficient and was used in o,o and p,p coupling of various phenols and in the formation of quinones under aerobic conditions. The dimerisation of substitued naphthols was also studied.
These C-H activation with formation of one C-C bond and one harmless molecule of water with air as oxidant at room temperature represent a biomimetic model of enzyme Laccase.
Keywords: green chemistry; aerobic oxidation; C-H activation; Cu complexe; phenols;
