An efficient synthesis and antibacterial activity of some novel 3,4&ndash;Dihydropyrimidin-2-(1H)-ones

¹ Department of Chemistry, Pratap College, Amalner 425401, India
² Department of Applied Science and Humanities, R. C. Patel Institute of Technology, Shirpur 425405, India
³ DNCVPS, Shirish Madhukarrao Chaudhari College, Jalgaon Tal. and Dist. Jalgaon- 425 001

Academic Editor: Julio A. Seijas

Published: 14 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry

https://doi.org/10.3390/ecsoc-25-11720

Abstract:

We have efficiently synthesized mono as well as bis and also spirocyclic products of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) by refluxing a reaction mixture of the three components in Deep Eutectic Solvent (DES) to generating “libraries from libraries”. Synthesized spirofused heterotricyclic compounds containing urea moiety is potent against bacteria. Overall antibacterial study, from the synthesised compounds. Some of 3, 4–dihydropyrimidin-2-(1H)-ones compounds were found to possess anti-bacterial efficacy.

Keywords: 3,4-dihydropyrimidin-2(1H)-ones, bis-dihydropyrimidinones, spirofused hetrotricyclic, Deep Eutetic Solvent and Antibacterial activity.

View paper

63 Reads
0 Recommendations

Nilesh Pawar

Pramod Patil

Rajashri Pachpande