In Situ Hemi-synthesis of new unexpected chiral chromeno-pyrimidine derivative

¹ Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (CRAPC), 42000 Tipaza, Algeria
² Université des frères Mentouri-Constantine 1, Département de chimie, Laboratoire d’Obtention des Substances Thérapeutiques (L.O.S.T), Campus Chaabet-Ersas, 25000, Constantine, Algeria
³ Université des Frères Mentouri Constantine 1, Unité de Recherche de Chimie de l’Environnement et Moléculaire Structurale CHEMS, 25000 Constantine, Algeria
⁴ Laboratoire de Recherche Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire ; faculté des sciences de la nature et de la vie de l’université de BATNA 2
⁵ Université des frères Mentouri-Constantine, Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (L.O.S.T), Campus Chaabet-Ersas, 25000 Constantine, Algeria

Academic Editor: György Keglevich

Published: 14 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-25-11737 (registering DOI)

Abstract:

A hemi-synthesis reaction of barbituric Acid with an α,β-unsaturated aldehyde using Perillaldehyde from Essential oil of Ammodaucus leucotrichus subsp leucotrichus, affording to a chromeno-pyrimidine derivative. The reaction was carried out in Water/Ethanol medium without an added catalyst. The obtained pyrimidine was identified by their spectral ¹H, ¹³C, HMBC and HSQC 2D NMR.

Keywords: Hemi-synthesis; Barbituric Acid; Chromeno-Pyrimidine; Chiral Perillaldehyde

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