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Para-Aminobenzoic acid-functionalized silica-coated magnetic nanoparticles: a highly efficient and synergistic organocatalyst for on-water synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Published:
14 November 2021
by MDPI
in The 25th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
https://doi.org/10.3390/ecsoc-25-11772
(registering DOI)
Abstract:
New para-aminobenzoic acid (PABA) grafted on silica-coated magnetic nanoparticles (Fe3O4@SiO2@Pr-PABA) were prepared. The efficiency of the new Fe3O4@SiO2@Pr-PABA nanoparticles, as a heterogenous nanocatalyst, was examined in the synthesis of biologically-active 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-one derivatives via one-pot three-component condensation of isatoic anhydride, aromatic aldehydes and aromatic amine on water under reflux conditions. The advantages of this green protocol are low catalyst loading, high to quantitative yields of the favorable products, short reaction times and easy separation and recycle of catalyst.
Keywords: Para-Aminobenzoic acid-functionalized silica-coated magnetic nanoparticles; Supported organocatalyst; On-Water synthesis; 2,3-Dihydroquinazolin-4(1H)-ones.
