A new hybrid molecules based on (5Z,9Z)-icosa-5,9-dienoic acid and monocarbonyl derivatives of curcuminoids

Published: 16 November 2022 by MDPI in The 26th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-26-13636

Abstract:

Efficient methods for the synthesis of previously undescribed hybrid compounds based on monocarbonyl derivatives of curcumin and 5Z,9Z-dienoic acid with yields of 58-66% was presented. The key monomer, (5Z,9Z)-icosa-5,9-dienoic acid was prepared using the stereoselective cross-cyclomagnesiation reaction of aliphatic and oxygen-containing 1,2-dienes catalyzed by Cp₂TiCl₂.

Keywords: 1,5-Dienoic compounds; cross-cyclomagnesiation, Grignard reagents, fatty acids, curcuminoids

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