Polypeptides have been obtained for use as carriers in polymer dosage forms containing macro- and microelements. It has been established that the optimal conditions for obtaining water-soluble polypeptides with an average molecular weight of 70,000-75,000 kDa with a maximum yield by hydrolysis of the silkworm cocoon (Bombyx mori) with caustic alkali solutions (NaOH, KOH) are: the concentration of the alkali solution is 0.250 N, the temperature of the system is 373 K, the reaction time is 80 minutes. Research has determined that the resulting polypeptides do not have a negative impact on the health of animals, do not cause local irritant effects on the skin and mucous membranes of the eyes, and do not have a cumulative property.
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POLYPEPTIDES FROM THE COCOON OF BOMBYX MORI AND THEIR BIOLOGICAL ACTIVITY
Published: 17 November 2022 by MDPI in The 26th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
https://doi.org/10.3390/ecsoc-26-13682 (registering DOI)
Keywords: polypeptides from Bombyx mori, polymer substrate, hydrolysis, potentiometry, microscopy, electrophoresis, toxicity, local irritant effect, cumulative effect, morphology, biochemistry.