Reaction of 2-amino-4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]-benzimidazoles with diethyl ethoxymethylenemalonate

Anton Dolzhenko; Anna Dolzhenko; Wai-Keung Chui

doi:10.3390/ecsoc-10-01381

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Reaction of 2-amino-4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]-benzimidazoles with diethyl ethoxymethylenemalonate

Anton V. Dolzhenko

^*,

Anna V. Dolzhenko

Wai-Keung Chui

¹ Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore

Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-10-01381

Abstract: The reaction of 2-amino-4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]-benzimidazoles with diethyl ethoxymethylenemalonate was found to afford 6-aryl-3-carbethoxy-4-oxo-4,6-dihydro-1(12)(13)H-pyrimido[2’,1’:4,5][1,3,5]triazino[1,2-a]benzimidazoles. The structure of the compounds obtained was established using NMR spectroscopy, including 2D NOESY experiments.

Keywords: triazines, benzimidazoles, pyrimidines, cyclization

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