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Stereochemical implications of remdesivir in combating the COVID-19
Jeremias J Emídio
1 ,
Paulo SDS Pereira
1 ,
Igor MA De Araujo
1 ,
Jessica P De Moura
1 ,
Teresa CML Rodrigues
1 ,
Nikole D Trigueiro
1 ,
Luciana Scotti
1, 2 ,
Alex France Messias Monteiro
* 1
1  Postgraduate Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, Castelo Branco - João Pessoa - Brazil
2  Teaching and Research Management - University Hospital, Federal University of Paraíba, João Pessoa, PB, Brazil
Academic Editor: Humbert G. Díaz
Published: 05 March 2023 by MDPI in MOL2NET'23, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 9th ed. congress CHEMBIO.MOL-09: Org. Chem., Med. Chem., Mol. Biol., & Pharm. Industry Congress, Paris, France-Fargo, USA, 2023.
https://doi.org/10.3390/mol2net-09-14117 (registering DOI)
Abstract:

The covid-19 is an infectious disease of the repertory tract caused by beta coronavirus, a disease that was considered a pandemic by the World Health Organization (WHO) in March 2020. Currently several vaccines are available for the prevention of covid-19, however few drugs have been shown to be effective in combating the current coronavirus, with remdesivir being the only approved drug Food and Drug Administratio (FDA). The remdesivir has two diastereoisomers due to the presence of a chiral phosphorous atom in its molecule, and the diastereomer-(Sp) is used in the clinic.

Keywords: Chemical; pharmacochemistry; chemoinformatics
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Comments on this paper
Shan He
28 December 2023
What ongoing research or developments are underway to explore alternative drugs or treatments beyond remdesivir in the fight against COVID-19, and how might a deeper understanding of the pharmacological differences between remdesivir's diastereoisomers contribute to the development of more effective antiviral therapies?


 
 
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