Mangrove is an opulent and untapped ecosystem with great phytochemical diversity thus suitable for discovery of novel antimicrobial compounds. The goal of the study was to explore the pharmaceutical antibacterial and anti-oxidant resources from Bruguiera gymnorrhiza, Ceriops tagal, Rhizophora mucronata, and Aegiceras corniculatum and gain an insight into the diversity and novelty of compounds line alkaloids, flavonol, polyphenols etc. Liquid extract was obtained by subjecting fresh mangrove leaves to Maceration & Soxhlet extraction. Plant DNA barcoding was utilized to authenticate the identity of the samples under study. Few obtained sequences have been communicated to GenBank (under review, accession number awaited). The phytochemical profiling revealed presence of polyphenols (TPC= 8.71,8.51, 8.77,5.52 mg/gm of plant tissue resp.); flavonoids (TFC= 12.42, 8.48, 5.26, 13.903 mg/gm of plant tissue resp.); alkaloids (2.5, 3.81, 4.98, 5.21 mg/gm of plant tissue resp.). The antioxidant potential (radical scavenging activity) was scored to be 87.8%, 89.5%, 92.07%, 45.8% (DPPH assay was conducted). The antimicrobial analysis was performed on Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Bacillus subtilus. The MIC revealed maximum activity Klebsiella pneumonia, while a negligible activity was scored on Staphylococcus aureus, Escherichia coli. The analysis thus reveals that the plants under study may have better medicinal activity against the respiratory tract organism. From the literature source few compounds were selected and In-silico based PK/PD analysis is carried out using Swiss-ADME server. The present study thus reveals the preliminary compounds from selected mangrove plants that can be promising future anti-microbial therapeutics.