Leishmaniasis is a significant global health problem caused by parasites transmitted through sandflies. Current treatments have limitations, and the lack of vaccines necessitates the exploration of new therapeutic options. One potential target is a protein called glycoprotein 63 (gp63), found on the surface of Leishmania parasites, which plays a role in the parasite's virulence. Computational methods, including molecular docking, can help predict protein structures and interactions with small molecules. This study presents a three-dimensional model of gp63 from Leishmania panamensis, validated for reliability. Molecular docking was used to analyze the binding of flavonoid compounds with gp63 from L. major and L. panamensis, providing insights for potential inhibitors. Another study discusses the importance of arginase, an enzyme involved in the parasite's survival, as a therapeutic target for Leishmania. Arginase inhibitors have shown promise in controlling infection by inducing oxidative stress in the parasite. Natural compounds, particularly flavonoids, have shown promise as arginase inhibitors and potential therapeutic agents against leishmaniasis.
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Question for Authors:
How does molecular docking assist in the identification of potential inhibitors for gp63 in Leishmania parasites, and what role do flavonoid compounds play in this process?
Could you elaborate on the mechanisms by which arginase inhibitors, particularly flavonoids, demonstrate promise as therapeutic agents against leishmaniasis, focusing on their impact on parasite survival and the induction of oxidative stress?
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Thank you for your contribution to our conference MOL2NET-09, Conference on Molecular, Biomedical, Computational, & Network Science and Engineering, ISSN: 2624-5078, MDPI SciForum, Basel, Switzerland, 2023.
At this time the conference is closed for submissions and we have started the Post-publication round with online questions/comments to the authors through the event REVIEWWWERS.PUB-09, Reviewers, Pre-Prints, & Post-Publication Workshop, Bilbao- Miami, USA, 2023.
Regarding your work, we have the following question for the author(s):
According to your opinion can Leishmaniasis be considered a rare, orpham, and/or neglected disease?
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