Epigallocatechin gallate is a tea catechin. It is the most abundant tea polyphenol, followed by other polyphenols such as catechin, epicatechin, epicatechin-3-gallate and epigallocatechin. The most important pharmacological activities of Epigallocatechin gallate are antineoplastic, HIV infection, hypertension, and associated complications, type II diabetes mellitus, its application as hepatoprotective, cardioprotective, nephroprotective, and its application in Parkinson, Alzheimer, and Osteoporosis. It has been also considered as the most important natural product in cancer treatment due to its safety, natural origin, and low cost. It has also ability to ameliorate protein and lipid damage induced by hepatotoxin. It carries also an important role in food industry. It is found in green tea, black tea, strawberries, cranberries, kiwis, cherries, apples, peaches, hazelnuts, pistachios, and pecans.